Thierry Blondeau was born in France in 1961. He studied music and literature at the Conservatoire de Paris and the Hochschule der Künste in Berlin.

He completed a residency at the Villa Médicis in Rome from 1994 to 1996 and was a fellow of the Villa Médicis hors-les-murs in 1998 for a collaboration with the Museum Tinguely in Basel, Switzerland. Between 1998 and 2002, he was a composer-in-residence at the École nationale de musique de Brest, the Akademie Schloss Solitude, and in Annecy, where he participated in the founding of MIA (Musiques inventives d’Annecy). In 2002 and 2003, he was a guest of the DAAD program in Berlin, and in 2006, a guest of the Künstlerhof Schreyahn in Lower Saxony.

Since 2003, he has taught acoustic and electroacoustic composition at the Université Marc Bloch in Strasbourg, in addition to teaching composition at the Conservatoire of Aulnay-sous-bois and the Conservatoire de Blanc-Mesnil. Many of his compositions are pedagogical. In 2004, with Jean-Luc Hervé and Oliver Schneller, he founded the Biotop(e) Initiative, which invites listeners to explore musical works in relationship to their spatial and temporal surroundings, expanding beyond what occurs during the playing of a given piece to the time before and after.